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dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorYardım, Yavuz
dc.contributor.authorŞentürk, Zühre
dc.date.accessioned2021-03-23T07:41:05Z
dc.date.available2021-03-23T07:41:05Z
dc.date.issued2014-07-17en_US
dc.identifier.citationLevent, A., Yardım, Y., Şentürk, Z. (2014). Electrochemical performance of boron-doped diamond electrode in surfactant-containing media for ambroxol determination. Sensors and Actuators, B: Chemical, 203, pp. 517-526. https://doi.org/10.1016/j.snb.2014.07.035en_US
dc.identifier.issn0925-4005
dc.identifier.urihttps://doi.org/10.1016/j.snb.2014.07.035
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2764
dc.description.abstractA novel application of boron-doped diamond electrode is introduced for the determination of ambroxol, a potential antioxidant drug belonging to the expectorant class. The electrochemical oxidation of ambroxol was first investigated by cyclic voltammetry using boron-doped diamond and glassy carbon electrodes in aqueous solutions both with and without the addition of surfactant. The compound was irreversibly oxidized in one/two steps at high positive potentials, resulting in the formation of a couple with a reduction and re-oxidation wave at less positive potentials. Special attention was given to the use of adsorptive stripping voltammetry at a surface of mildly oxidized boron-doped diamond electrode in aqueous solutions over the pH range of 1.0–10.0. Addition of anionic surfactant (sodium dodecylsulfate) to ambroxol-containing electrolyte enhanced the stripping current signal. Using square-wave stripping mode, the drug yielded a well-defined voltammetric response in phosphate buffer pH 2.5 containing 4 × 10−4 M sodium dodecylsulfate at +1.02 V (versus Ag/AgCl) (after 30 s accumulation at +0.50 V). The process could be used to determine ambroxol in the concentration range of 0.05–0.7 μM, with a detection limit of 0.010 μM (4.2 ng mL−1). The suggested method was successfully applied to pharmaceuticals and spiked human urine samples.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.1016/j.snb.2014.07.035en_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAmbroxolen_US
dc.subjectBoron-Doped Diamond Electrodeen_US
dc.subjectSodium Dodecylsulfateen_US
dc.subjectAdsorptive Stripping Voltammetryen_US
dc.subjectReal Samplesen_US
dc.titleElectrochemical performance of boron-doped diamond electrode in surfactant-containing media for ambroxol determinationen_US
dc.typearticleen_US
dc.relation.journalSensors and Actuators, B: Chemicalen_US
dc.contributor.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.contributor.authorID0000-0001-5792-419Xen_US
dc.identifier.volume203en_US
dc.identifier.startpage517en_US
dc.identifier.endpage526en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US


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