Electrochemical determination of melatonin hormone using a boron-doped diamond electrode
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CitationLevent, A. (2012). Electrochemical determination of melatonin hormone using a boron-doped diamond electrode. Diamond and Related Materials, 21 , pp. 114-119. https://doi.org/10.1016/j.diamond.2011.10.018.
In this study, a boron-doped diamond electrode was used for the electroanalytical determination of melatonin in the pharmaceutical tablet and urine samples by square-wave voltammetry. Melatonin yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 3.0 at + 0.88 V (vs. Ag/AgCl). Using the optimal square-wave voltammetry conditions, the oxidation peak was used to determine melatonin in the concentration range of 5.0 × 107 M to 4.0 × 106 M (r = 0.998, n = 8), a detection limit of 1.1 × 107 M (0.025 μg/mL) and relative standard deviation was 2.06% at the 2.0 × 106 M level (n = 10). Recoveries of melatonin were in the range of 97.67–105%, for both tablet and spiked human urine samples.
SourceDiamond and Related Materials
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