New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode
CitationAltunkaynak, Y., Yavuz, Ö., Levent, A. (2020). New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.
Metformin(MET), an oral antidiabetic drug commonly used in the treatment of diabetes, is a drug that increases insulin sensitivity in the biguanide group . MET shows its pharmacological effect by lowering the glucose level in the blood. In the literature research, there are studies using electrochemical techniques for the analysis of MET in biological fluid and drug forms[1-6]. In this study, the electrochemical properties of MET, one of the drugs used in the treatment of diabetes, were performed using a pencil graphite electrode in NaOH (0.1 M) solution. This compound was recorded with an irreversible and diffusion controlled adsorption oxidation peak at approximately +1.28 V by cyclic voltammetry. With square wave stripping voltammetry, it was observed that the peak current signals of MET in the concentration range of 2.76-24.8 µM in 0.1M NaOH solution increased linearly. At a concentration of 2.76 µM (n = 9), the limit of detection and relative standard deviation were calculated as 9.03 nM (1.495 ngmL-1 ) and 3.25 %, respectively. This method has been successfully applied for MET analysis in pharmaceutical preparations and urine samples without any separation.
Source6th International Conference on New Trends in Chemistry, 17-18 October 2020
The following license files are associated with this item: