Electrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetry
Citation
Altunkaynak, Y., Yavuz, Ö., Levent, A. (2020). Electrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetry. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.Abstract
Vildagliptin (VLDG), one of the antidiabetic agents, is a dipeptidyl peptidase 4 inhibitor. It is
a drug developed for oral administration[1]. In the literature, there is only one study in which
electrochemical methods were used for the analysis of Vildagliptin in biological fluid and
drug forms[2]. In this study, the electrochemical properties of VLDG, which is one of the
drugs used as an antidiabetic agent, were determined by using pencil graphite electrode in
phosphate buffer solution (PBS/pH 9.0). The irreversible and diffusion controlled adsorption
oxidation peak was measured by cyclic voltammetry at approximately +1.13 V for this
compound. Using square wave stripping voltammetry, the current showed a linear correlation
in PBS buffer at pH 9.0, with a concentration range of 2.94 to 49.98 µM. At a concentration
of 2.94 µM (n=9), the limit of detection of 8.20 nM (2.48 ng mL-1
) and a relative standard
deviation of 2.95 % were calculated. This method was successfully applied for VLDG
analysis without any separation in pharmaceutical preparations and urine samples
Source
6th International Conference on New Trends in Chemistry, 17-18 October 2020The following license files are associated with this item: