New voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode
CitationAslan, M., Levent, A. (2020). New voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.
Various drugs made of metal compounds have been used in many diseases including cancer. Studies on Oxaliplatin in the literature are these [2-6]. Oxaliplatin (OxPt), which is a platinum analogue with anti-cancer effect, was accentuated. OxPt is separated from cisplatin, one of analogues of platinum, by replacing 1,2-diaminocyclohexane with amine groups. In this study, a simple, fast and sensitive voltammetric method was developed for OxPt which shows anticancer effects with cytotoxic properties. The boron-doped diamond (BDD) electrode was activated electrochemically in cathodic direction in 0.5 M H2SO4 medium. Electrochemical properties of OxPt were investigated on BDD electrode surface using square-wave and cyclic voltammetry techniques. OxPt in Britton-Robinson(BR) buffer (pH 5.0) gave a well-determined voltammetric response at +1.01 V (vs. Ag/AgCl) using the square-wave voltammetry technique. The developed voltammetric technique was found to be linear with the concentration range of 1.0-3.5 μM in the BR (pH 5.0) medium and the limit of detection was 0.276 μM (0.109 μg mL-1 ). Recommended method was successfully applied to drug forms of OxPt.
Source6th International Conference on New Trends in Chemistry, 17-18 October 2020
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