Aslan, MehmetLevent, Abdulkadir2021-03-222021-03-222020Aslan, M., Levent, A. (2020). New voltammetric strategy for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode. Journal of the Indian Chemical Society, 97, pp. 1-120019-4522https://hdl.handle.net/20.500.12402/2747Various drugs made of metal compounds have been used in many diseases including cancer[1]. Studies on Oxaliplatin in the literature are these [2-6]. Oxaliplatin (OxPt), which is a platinum analogue with anti-cancer effect, was accentuated. OxPt is separated from cisplatin, one of analogues of platinum, by replacing 1,2-diaminocyclohexane with amine groups. In this study, a simple, fast and sensitive voltammetric method was developed for OxPt which shows anticancer effects with cytotoxic properties. The boron-doped diamond (BDD) electrode was activated electrochemically in cathodic direction in 0.5 M H2SO4 medium. Electrochemical properties of OxPt were investigated on BDD electrode surface using square-wave and cyclic voltammetry techniques. OxPt in Britton-Robinson(BR) buffer (pH 5.0) gave a well-determined voltammetric response at +1.01 V (vs. Ag/AgCl) using the square-wave voltammetry technique. The developed voltammetric technique was found to be linear with the concentration range of 1.0-3.5 μM in the BR (pH 5.0) medium and the limit of detection was 0.276 μM (0.109 μg mL-1 ). Recommended method was successfully applied to drug forms of OxPt.eninfo:eu-repo/semantics/closedAccessOxalipaltinBoron-Doped DiamondVoltammetryArticle97112Q4Q4