Önal, GünayAltunkaynak, YalçınLevent, Abdulkadir2021-03-242021-03-242020Önal, G., Altunkaynak, Y., Levent, A. (2020). Application of bismuth film electrode in determination of Loratadine by cathodic stripping voltammetry in the presence of cationic surfactant. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.9786056747656https://hdl.handle.net/20.500.12402/2782Loratadine, histamine - H1 antihistamine receptors it is being used for many years in the treatment of an allergic condition illustrating the effects on[1]. When the literature is reviewed, there are limited number of studies on Loratadine based on electrochemistry [2-5]. Stripping voltammetry is a very sensitive and selective method for determining drugs and organic / inorganic substances in biological fluids. The electrochemical behavior of Loratadine with BiFE in different supporting electrolyte and pH values, and its performance characteristics in electroanalytical determinations were investigated by cyclic voltammetry and linear sweep cathodic stripping voltammetry (LS-CSV) methods. LS-CSV measurements on the BiFE surface of 6.5x10-4 M Loratadine in 0.04 M BR buffer (pH 7.0) and 4 mM cationic surfactant (CTAB) were taken between 0.0 V and -2.0 V. Loratadine gave a voltammetric response about at -1.486 V. The limit of detection was found LOD = 1.2x10-7 M* at the BIFE surface at liner concentration range [1.305x10-6 M – 14.3x10-6 M, r = 0,998* (n = 11)]. This voltammetric method, developed under optimum conditions, has been successfully applied to pharmaceutical formulations of Loratadin as fast, easy to apply, sensitive and environmentally friendly.eninfo:eu-repo/semantics/closedAccessAttribution-NonCommercial-ShareAlike 3.0 United StatesLoratadineBiFEVoltammetryPharmaceutical FormulationConference Object