Dağ, BeşirYaşar, FevziKızılkaya, Hakan2021-04-142021-04-142017Dağ, B., Yaşar, F., Kızılkaya, H. (2017). Synthesis characterization and using some of schiff base ligands derived from 4 aminoantipyrine as an inhibitor. International Conference on Engineering Technologies (ICENTE'17), 07-09 December 2017, Konya.9786056753558https://hdl.handle.net/20.500.12402/2861Schiff bases and their complexes are widely studied because of the increasing recognition of their role in biological systems. In azo methine derivatives, the C=N linkage is essential for biological activity; several azomethines were reported to possess remarkable antibacterial and antifungal, anticancer. With the increasing incidence of deep mycosis, there has been increasing emphasis on the screening of new and more effective antimicrobial drugs with low toxicity. These compounds were recently found to have significant antitumor and biological activity. Antipyrine derivatives are reported to exhibit analgesic and antiinflammatory effects, antiviral, antibacterial, and herbicidal activities, and have also been used as hair color additives and to potentiate the local anesthetic effect of Lidocaine. Transition metal complexes with ligands derived from 4-aminoantipyrine have significant biological activity. This prompted us to synthesize a new series of heterocyclic Schiff bases containing the antipyrinyl moiety. The present study reports synthesis and charaterization of Schiff bases derived from 1-phenyl-2,3-dimethyl-4-(N-2 hydroxybenzylidene)-3- pyrazolin-5-one and 1-phenyl-2,3-dimethyl-4-(N-2-hydroxynaphthylidene)-3-pyrazolin-5- one with 5-aminoisophtlalic acid [1-2]. These compounds were synthesized in high yield and characterized by SEM, FT–IR, 1H NMR and 13C NMR.eninfo:eu-repo/semantics/closedAccessSchiff Base4-AminoantipyrineConference Object