Graphene/Nafion composite film modified glassy carbon electrode for simultaneous determination of paracetamol, aspirin and caffeine in pharmaceutical formulations

Abstract

A graphene-Nafion compositefilm was fabricated on the glassy carbon electrode (GR-NF/GCE), and usedfor simultaneous determination of paracetamol (PAR), aspirin (ASA) and caffeine (CAF). The electro-chemical behaviors of PAR, ASA and CAF were investigated by cyclic voltammetry and square-waveadsorptive anodic stripping voltammetry. By using stripping one for simultaneous determination of PAR,ASA and CAF, their electrochemical oxidation peaks appeared atþ0.64, 1.04 and 1.44 V, and good linearcurrent responses were obtained with the detection limits of 18 ng mL 1(1.2 10 9M), 11.7 ng mL 1(6.5 10 8M) and 7.3 ng mL 1(3.8 10 8M), respectively. Finally, the proposed electrochemical sensorwas successfully applied for quantifying PAR, ASA and CAF in commercial tablet formulations.