The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats

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dc.authorid0000-0001-7310-7800en_US
dc.authorid0000-0002-6502-5028en_US
dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorOto, Gökhan
dc.contributor.authorEkin, Suat
dc.contributor.authorÖzdemir, Hülya
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorBerber, İsmet
dc.date.accessioned2021-03-23T11:25:42Z
dc.date.available2021-03-23T11:25:42Z
dc.date.issued2012-04en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.description.abstractThe present study was designed to evaluate the effect of Plantago major Linnaeus (PM) extract on serum total sialic acid (TSA), lipid-bound sialic acid (LSA), some trace elements (copper (Cu), zinc (Zn) and iron) and mineral levels (magnesium, calcium and sodium) in Wistar albino rat administrated 7,12-dimethylbenz(a)anthracene (DMBA). Rats were divided into three equal groups (n = 6). Group I comprised the control group, group II was treated with DMBA (100 mg/kg, single dose) and group III was treated with DMBA (100 mg/kg single dose) and aqueous extract of PM 100 mg/kg/day for 60 days. After 60 days, statistical analyses showed that TSA and LSA levels in DMBA and DMBA + PM groups were significantly higher compared to the control group (TSA: p < 0.01, p < 0.05; LSA: p < 0.05, p < 0.05, respectively). Serum Zn levels were decreased in subjects treated with DMBA (p < 0.01) and DMBA + PM (p < 0.05) compared to the control group values. Serum Cu levels were increased in DMBA group and PM-treated group compared to the control group values. The results of this investigation showed that the levels of TSA and LSA changed significantly, which are sensitive markers for detecting the toxic effects of DMBA. On the other hand, observed decline in Zn levels in rats from DMBA + PM group might be due to decreased generation of free radicals and oxidative stress. Results from this study suggest that PM may be partially effective in preventing carcinogenesis initiated by environmental carcinogen DMBA.en_US
dc.identifier.citationOto, G., Ekin, S., Özdemir, H., Levent, A., Berber, İ. (2012). The effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in rats. Toxicology and Industrial Health, 28 (4), pp. 334-342. https://doi.org/10.1177/0748233711412422en_US
dc.identifier.endpage342en_US
dc.identifier.issn0748-2337
dc.identifier.issn1477-0393
dc.identifier.issue4en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage334en_US
dc.identifier.urihttps://doi.org/10.1177/0748233711412422
dc.identifier.urihttps://journals.sagepub.com/doi/pdf/10.1177/0748233711412422
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2770
dc.identifier.volume28en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherSAGEen_US
dc.relation.isversionof10.1177/0748233711412422en_US
dc.relation.journalToxicology and Industrial Healthen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/embargoedAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectDMBAen_US
dc.subjectLSAen_US
dc.subjectPlantago Major L.en_US
dc.subjectTrace Elementsen_US
dc.subjectTSAen_US
dc.titleThe effect of Plantago major Linnaeus on serum total sialic acid, lipid-bound sialic acid, some trace elements and minerals after administration of 7,12-dimethylbenz(a)anthracene in ratsen_US
dc.typeArticleen_US

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