Simultaneous electrochemical evaluation of ascorbic acid, epinephrine and uric acid at disposable pencil graphite electrode: Highly sensitive determination in pharmaceuticals and biological liquids by differential pulse voltammetry

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dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorÖnal, Günay
dc.date.accessioned2021-03-22T11:22:18Z
dc.date.available2021-03-22T11:22:18Z
dc.date.issued2018en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.departmentBatman Üniversitesi Sağlık Hizmetleri Meslek Yüksekokulu Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.description.abstractAim and Objective: As is known, AA, EP and UA can also coexist in biological fluids. Therefore, the determination of the levels of these compounds in biological fluids is extremely important both for the diagnosis and treatment of the related diseases. In the presence of many interfering substances in biological fluids such as blood and urine samples, it is very important that these compounds can be selectively analyzed. Materials and Methods: All electrochemical experiments were performed using an Autolab PGSTAT 128N potentiostat. Before beginning the electrochemical measurements, the PGE was activated. The electrochemical pretreatment of PG was exercised by anodically +1.40 V for 60 s. Then, measurements were performed with CV (-0.4 V to 1.2 V) and DPV (-0.2 V to 0.7 V) for single and simultaneous voltammetric behaviour of AA, EP, and UA in the electrochemical method. Results: The anodic peak potentials of AA and UA were observed at about +0.32 V and +0.62 V, respectively. On the other hand, for EP, while anodic peak potential was observed at about +0.53 V, in the reverse scan, cathodic peak potentials were observed at about +0.41 V and +0.007 V. The39 reduction peak observed at +0.3 V with the oxidation peak observed at +0.53 V are the reversible peaks. In the method developed for the electrochemical simultaneous determination of AA, EP and UA using PGE with DPV technique in BR buffer solution (pH 4.0), the anodic peak potentials are sufficiently separated from each other. Conclusion: A voltammetric method was developed for the simultaneous determination of AA, EP and UA with PGE for the first time. Here, the most important thing is that the simultaneous determination of AA, EP and UA was successfully achieved with that targeted voltammetric method which was sensitive, low-cost, practical and well-repeated; and that these were proven to be selectively applicable in pharmaceutical products and biological liquids.en_US
dc.identifier.citationLevent, A., Önal, G. (2018). Simultaneous electrochemical evaluation of ascorbic acid, epinephrine and uric acid at disposable pencil graphite electrode: Highly sensitive determination in pharmaceuticals and biological liquids by differential pulse voltammetry. Combinatorial Chemistry and High Throughput Screening, 21 (7), pp. 516-525. https://doi.org/10.2174/1386207321666180914120839en_US
dc.identifier.endpage525en_US
dc.identifier.issn1386-2073
dc.identifier.issn1875-5402
dc.identifier.issue7en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage516en_US
dc.identifier.uri:https://doi.org/10.2174/1386207321666180914120839
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2752
dc.identifier.volume21en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.isversionof10.2174/1386207321666180914120839en_US
dc.relation.journalCombinatorial Chemistry and High Throughput Screeningen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPencil Graphite Electrodeen_US
dc.subjectAscorbic Aciden_US
dc.subjectEpinephrineen_US
dc.subjectUric Aciden_US
dc.subjectSimultaneousen_US
dc.subjectBiological Liquidsen_US
dc.titleSimultaneous electrochemical evaluation of ascorbic acid, epinephrine and uric acid at disposable pencil graphite electrode: Highly sensitive determination in pharmaceuticals and biological liquids by differential pulse voltammetryen_US
dc.typeArticleen_US

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Fen - Edebiyat Fakültesi, Kimya Bölümü, Makale Koleksiyonu
Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümü, Makale Koleksiyonu
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