The changes in the serum, liver, kidney protein and genomic DNA profiles in rats treated with 7,12-Dimethylbenz(A) anthracene and Plantago major L.

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dc.authorid0000-0002-6502-5028en_US
dc.authorid0000-0001-5792-419Xen_US
dc.authorid0000-0001-7310-7800en_US
dc.contributor.authorBerber, İsmet
dc.contributor.authorEkin, Suat
dc.contributor.authorLevent, Abdulkadir
dc.contributor.authorOto, Gökhan
dc.contributor.author
dc.date.accessioned2021-03-23T06:48:22Z
dc.date.available2021-03-23T06:48:22Z
dc.date.issued2014-01en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.description.abstractIn the study, the changes in the serum, liver, kidney protein and genomic DNA profiles in Wistar albino rats administrated to 7,12-dimethylbenz(a)anthracene (DMBA) and Plantagomajor L. were investigated. SDS-PAGE profiling of the serum proteins showed that the levels of two proteins molecular weighing 140.8 kDa and 46.8 kDa were significantly lower on the 0th day of treatment than on the 60th day of application in the groups. Furthermore, two proteins (34.5 and 22.3 kDa) were solely present in DMBA-treated liver cell lysates. On the contrary, the kidney protein profiles did not show significant banding variations in groups. Genomic DNA analysis also confirmed that DNA extracted from liver and kidney cells did not fragment in any of the groups after the 60th study day. The proteins 34.5 and 22.3 kDa in liver cell lysates at the 60th day in DMBA-treated group could be extra-prognostic indicators for severe DMBA toxicity.en_US
dc.identifier.citationBerber, İ., Ekin, S., Levent, A., Oto, G. (2014). The changes in the serum, liver, kidney protein and genomic DNA profiles in rats treated with 7,12-Dimethylbenz(A) anthracene and Plantago major L.. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 5 (1), pp. 253-260.en_US
dc.identifier.endpage260en_US
dc.identifier.issn0975-8585
dc.identifier.issue1en_US
dc.identifier.scopusqualityN/Aen_US
dc.identifier.startpage253en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2759
dc.identifier.volume5en_US
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherRJPBCSen_US
dc.relation.journalResearch Journal of Pharmaceutical, Biological and Chemical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectDMBAen_US
dc.subjectGenomic DNAen_US
dc.subjectPlantagomajor L.en_US
dc.subjectProtein Profilesen_US
dc.titleThe changes in the serum, liver, kidney protein and genomic DNA profiles in rats treated with 7,12-Dimethylbenz(A) anthracene and Plantago major L.en_US
dc.typeArticleen_US

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