New voltammetric strategy for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode
| dc.authorid | 0000-0001-5792-419X | en_US |
| dc.contributor.author | Aslan, Mehmet | |
| dc.contributor.author | Levent, Abdulkadir | |
| dc.date.accessioned | 2021-03-22T09:41:55Z | |
| dc.date.available | 2021-03-22T09:41:55Z | |
| dc.date.issued | 2020 | en_US |
| dc.department | Batman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümü | en_US |
| dc.description.abstract | Various drugs made of metal compounds have been used in many diseases including cancer[1]. Studies on Oxaliplatin in the literature are these [2-6]. Oxaliplatin (OxPt), which is a platinum analogue with anti-cancer effect, was accentuated. OxPt is separated from cisplatin, one of analogues of platinum, by replacing 1,2-diaminocyclohexane with amine groups. In this study, a simple, fast and sensitive voltammetric method was developed for OxPt which shows anticancer effects with cytotoxic properties. The boron-doped diamond (BDD) electrode was activated electrochemically in cathodic direction in 0.5 M H2SO4 medium. Electrochemical properties of OxPt were investigated on BDD electrode surface using square-wave and cyclic voltammetry techniques. OxPt in Britton-Robinson(BR) buffer (pH 5.0) gave a well-determined voltammetric response at +1.01 V (vs. Ag/AgCl) using the square-wave voltammetry technique. The developed voltammetric technique was found to be linear with the concentration range of 1.0-3.5 μM in the BR (pH 5.0) medium and the limit of detection was 0.276 μM (0.109 μg mL-1 ). Recommended method was successfully applied to drug forms of OxPt. | en_US |
| dc.identifier.citation | Aslan, M., Levent, A. (2020). New voltammetric strategy for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode. Journal of the Indian Chemical Society, 97, pp. 1-12 | en_US |
| dc.identifier.endpage | 12 | en_US |
| dc.identifier.issn | 0019-4522 | |
| dc.identifier.scopusquality | Q4 | en_US |
| dc.identifier.startpage | 1 | en_US |
| dc.identifier.uri | https://hdl.handle.net/20.500.12402/2747 | |
| dc.identifier.volume | 97 | en_US |
| dc.identifier.wosquality | Q4 | en_US |
| dc.indekslendigikaynak | Web of Science | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Indian Chemical Society | en_US |
| dc.relation.journal | Journal of the Indian Chemical Society | en_US |
| dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Oxalipaltin | en_US |
| dc.subject | Boron-Doped Diamond | en_US |
| dc.subject | Voltammetry | en_US |
| dc.title | New voltammetric strategy for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode | en_US |
| dc.type | Article | en_US |
