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Öğe Docking and molecular dynamics calculations of some previously studied and newly designed ligands to catalytic core domain of HIV-1 integrase and an investigation to effects of conformational changes of protein on docking results(Türkiye Kimya Derneği, 2017-01-09) Ercan, SelamiNowadays, AIDS still remains as a worldwide pandemic and continues to cause many deaths which arise from HIV-1 virus. For nearly 35 years, drugs that target various steps of virus life cycle have been developed. HIV-1 integrase constitutes one of these steps which is essential for virus life cycle. Computer-aided drug design is being used in many drug development and drug improvement studies as also used in development of the first HIV-1 integrase inhibitor Raltegravir. In this study, 3 ligands which are already used as HIV-1 integrase inhibitors and 4 newly designed ligands were docked to catalytic core domain of HIV-1 integrase. Each ligand docked to three different conformations of protein. Prepared complexes (21 items) were carried out by 50 ns MD simulations and results were analyzed. Finally, the binding free energies of ligands were calculated. It was determined that designed ligands L01 and L03 gave favorable results. The questions about the ligands which have low docking scores in a conformation of protein could give better scores in another conformation of protein and if the MD simulations carry the different oriented and different localized ligands in same position at the end of simulation were answered.Öğe Experimental investigation of solar stills integrated with solar water heating collectors(Türk Isı Bilimi ve Tekniği Derneği, 2017-10-31) Argunhan, Zeki; El, Emin; Yıldız, Cengiz; Çakmak, GülşahSolar still is a more practical way of obtaining clean water. In this study, we aimed to improve the efficiency of solar still systems and obtain distilled water at the same time. For this purpose, 5 different solar still systems were designed. Type 1; conventional solar still, Type 2; conventional solar still integrated with solar water heating collector and run via natural convection, Type 3; conventional solar still integrated with solar water heating collector and tubular heat exchanger and run via natural convection, Type 4; conventional solar still placed with plate heat exchanger and integrated with solar water heating collector and run via natural convection, Type 5; conventional solar still placed with plate heat exchanger and integrated with solar water heating collector and run via forced convection. In this study, the experiments were carried out on the parameters influencing the performance, the amount of distilled water obtained, and the efficiency of experiment settings designed in different types; and finally the results were presented. The amount of distilled water and efficiency of conventional solar still were 2389 ml and 51.47%, respectively. Maximum total amount of water and efficiency from natural convection systems were obtained from Type 4, and the values calculated were found as to be 5788 ml and 55.91%. Maximum amount of distilled water and the efficiency were obtained by utilizing forced convection system were found as to be 6068 ml and 58.99%, respectively.Öğe Effect of the air flow rate of blower on the performance of solar still(Türk Isı Bilimi ve Tekniği Derneği, 2015-06-01) Argunhan, Zeki; El, Emin; Yücel, Halit Lutfi; Çakmak, Gülşah; Yıldız, CengizSolar distillation is one of the important methods for water purification. This paper examines the performance of solar distillation system at different air flow rate. To increase the performance of distiller, artificial wind was created by fan and suitable wind speed was investigated to increase the amount of water distilled. The experiments were carried out in Elazığ climate conditions. In order to examine the effect of the wind speed on solar distillation system, two stills were manufactured with the size of 1000x1000 mm. One of them was the conventional still which was used as a reference. The other still was used to investigate experimentally the effect of the wind speed. Graphs were drawn for time-dependent changes in the amount of water distilled. It was found that that the productivity of the fan-still distiller was 14.7 % greater than that of a conventional still.Öğe Extraction of lanthanum and cerium from a bastnasite ore by direct acidic leaching(TMMOB Maden Mühendisleri Odası, 2020-06-01) Özsaraç, Şafak; Kurşunoğlu, Sait; Hussaini, Shokrullah; Gökçen, Hasan Serkan; Kaya, Muammer; Altıner, Mahmut; Top, SonerThe extraction of lanthanum (La) and cerium (Ce) from a bastnasite ore by direct acidic leaching was investigated. The effects of acid concentration and leaching temperature on the extraction of La and Ce from the ore were tested. Using nitric (NHO3 ), more than 85% of the La and Ce were simultaneously extracted into leach solution whereas the La and Ce dissolutions were determined as less than 85% by using sulfuric acid (H2 SO4 ). The La dissolution exceeded 90% by using hydrochloric acid (HCl); however, the Ce dissolution remained below 85% under the following conditions: solid-to-liquid ratio of 20% (w/v), the acid concentration of 20%, leaching temperature of 25 °C and leaching time of 1 h. The result revealed that HNO3 could be used as a solvent for the maximum simultaneous extraction of the La and Ce from the bastnasite ore. The leaching temperature had no crucial effect on the dissolution of La and Ce when HNO3 or HCl solutions were preferred as a solvating agent. However, the leaching temperature had a slight positive effect on the dissolutions of La and Ce when H2 SO4 was used as a solvent.Öğe Çalışan performansının incelenmesi: Sağlık sektörü örneği(Sağlık Bilimleri Üniversitesi, 2017) Uzuntarla, Yasin; Ceyhan, Sümeyra; Fırat, İbrahimTanımlayıcı nitelikteki bu çalışmanın amacı, sağlık çalışanlarının performanslarının incelenmesi ve bazı sosyodemografik faktörlere göre farklılık varsa bunların tespit edilmesidir. Araştırma Bingöl ilindeki sağlık kurumlarında çalışan personel üzerinde uygulanmış olup, 105 kişiye ulaşılabilmiştir. Çalışmada anket yöntemi kullanılmıştır. İlk bölümde sosyodemografik özellikleri belirlemeye yönelik 6 madde, ikinci bölümde ise çalışan performansının belirlenmesine yönelik 25 madde yer almaktadır. Verilerin analizinde SPSS 22.0 programı kullanılmış olup frekans analizi, Bağımsız T testi, Mann Whitney-U testinden yararlanılmıştır. Çalışan performansı anketi puan ortalaması 45,06±10,95 bulunduğundan, katılımcıların performansının ortalamanın altında olduğu değerlendirilmektedir. Ayrıca sosyodemografik faktörlere göre çalışan performansı puan ortalamalarında istatistiksel olarak anlamlı bir farklılık bulunmamıştır. Çalışanların performansının yükseltilmesine yönelik müdahaleler yapılmasının ve sağlık yöneticilerinin konuyla ilgili farkındalıklarının oluşturulmasının olumlu katkı sağlayacağı düşünülmektedir.
