Electrochemical performance of boron-doped diamond electrode in surfactant-containing media for ambroxol determination
Yükleniyor...
Tarih
2014-07-17
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Attribution-NonCommercial-ShareAlike 3.0 United States
Attribution-NonCommercial-ShareAlike 3.0 United States
Özet
A novel application of boron-doped diamond electrode is introduced for the determination of ambroxol, a potential antioxidant drug belonging to the expectorant class. The electrochemical oxidation of ambroxol was first investigated by cyclic voltammetry using boron-doped diamond and glassy carbon electrodes in aqueous solutions both with and without the addition of surfactant. The compound was irreversibly oxidized in one/two steps at high positive potentials, resulting in the formation of a couple with a reduction and re-oxidation wave at less positive potentials. Special attention was given to the use of adsorptive stripping voltammetry at a surface of mildly oxidized boron-doped diamond electrode in aqueous solutions over the pH range of 1.0–10.0. Addition of anionic surfactant (sodium dodecylsulfate) to ambroxol-containing electrolyte enhanced the stripping current signal. Using square-wave stripping mode, the drug yielded a well-defined voltammetric response in phosphate buffer pH 2.5 containing 4 × 10−4 M sodium dodecylsulfate at +1.02 V (versus Ag/AgCl) (after 30 s accumulation at +0.50 V). The process could be used to determine ambroxol in the concentration range of 0.05–0.7 μM, with a detection limit of 0.010 μM (4.2 ng mL−1). The suggested method was successfully applied to pharmaceuticals and spiked human urine samples.
Açıklama
Anahtar Kelimeler
Ambroxol, Boron-Doped Diamond Electrode, Sodium Dodecylsulfate, Adsorptive Stripping Voltammetry, Real Samples
Kaynak
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
203
Sayı
Künye
Levent, A., Yardım, Y., Şentürk, Z. (2014). Electrochemical performance of boron-doped diamond electrode in surfactant-containing media for ambroxol determination. Sensors and Actuators, B: Chemical, 203, pp. 517-526. https://doi.org/10.1016/j.snb.2014.07.035
