Synthesis, characterization and antioxidant activity of heterocyclic Schiff bases

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dc.authorid0000-0002-6612-2751en_US
dc.contributor.authorAral, Tarık
dc.contributor.authorDağ, Beşir
dc.contributor.authorKızılkaya, Hakan
dc.contributor.authorGenç, Nusret
dc.contributor.authorErenler, Ramazan
dc.date.accessioned2021-03-23T06:36:25Z
dc.date.available2021-03-23T06:36:25Z
dc.date.issued2020-08-04en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.description.abstractSchiff base derivatives have gained great importance due to revealing a great number of biological properties. Schiff bases were synthesized by treatment of 4-amino-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (1) with various aldehydes in methanol at reflux. In addition, diamine was reacted with an aldehyde to yield the corresponding Schiff bases. The structures of synthesized Schiff bases were elucidated by spectroscopic methods such as microanalysis, 1 H-NMR, 13C-NMR, and FTIR. Antioxidant activities of synthesized Schiff bases were carried out using different antioxidant assays such as 1,1-diphenyl-2-picryl-hydrazyl free radical (DPPH• ) scavenging, 2,20 -azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging, and reducing power activity. (E)-4-((1H-indol-3-yl)methyleneamino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one (3), (E)-1,5-dimethyl-4-((2-methyl-1H-indol-3-yl) methyleneamino)-2-phenyl-1H-pyrazol-3(2H)-one (5), (E)-1,5-dimethyl-2-phenyl-4-(thiophen-2-ylmethyleneamino)-1H-pyrazol-3(2H)-one (7), (E)-1,5-dimethyl2-phenyl-4-(quinolin-2-ylmethyleneamino)-1H-pyrazol-3(2H)-one (9), (1S,2S, N1,N2)-N1,N2-bis((1H-indol-3-yl)methylene)cyclohexane-1,2-diamine (11), and (1S,2S,N1,N2)-N1,N2-bis((2-methyl-1H-indol-3-yl)methylene)cyclohexane-1,2-diamine (12) were synthesized in high yields. Compound 5 displayed a good ABTS•+ activity. Compound 3 revealed the outstanding activity in all assays. Compound 7 has the best-reducing power ability in comparison to other synthesized compounds. Although compounds 5, 11, 12 are new, compounds 3, 7, 9 are known. Due to revealing a good antioxidant activity, the synthesized compounds (3, 5, 7) have the potential to be used as synthetic antioxidant agents.en_US
dc.identifier.citationAral T., Dağ, B., Kızılkaya, H., Genç, N. ve Erenler, R. (2020). Synthesis, characterization and antioxidant activity of heterocyclic Schiff bases. Journal of the Chinese Chemical Society, 67 (9), 99. 1696–1701. https://dx.doi.org/10.1002/jccs.202000161en_US
dc.identifier.endpage1701en_US
dc.identifier.issn0009-4536
dc.identifier.issue9en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1696en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/jccs.202000161
dc.identifier.urihttps://dx.doi.org/10.1002/jccs.202000161
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2758
dc.identifier.volume67en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherJournal of the Chinese Chemical Societyen_US
dc.relation.isversionof10.1002/jccs.202000161en_US
dc.relation.journalJournal of the Chinese Chemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAntioxidant Activityen_US
dc.subjectChromatographyen_US
dc.subjectHeterocyclicen_US
dc.subjectSchiff Baseen_US
dc.subjectSpectroscopyen_US
dc.subjectSynthesisen_US
dc.titleSynthesis, characterization and antioxidant activity of heterocyclic Schiff basesen_US
dc.title.alternativeHeterosiklik Schiff bazlarının sentezi, karakterizasyonu ve antioksidan aktivitesien_US
dc.typeArticleen_US

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