A detailed biological and chemical investigation of 16 Achillea species’ essential oilsvia chemometric approach

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dc.authorid0000-0002-0988-9462en_US
dc.authorid0000-0001-5487-6786en_US
dc.authorid0000-0001-7016-1289en_US
dc.authorid0000-0003-1367-5624en_US
dc.authorid0000-0002-0761-6436en_US
dc.authorid0000-0002-2193-8386en_US
dc.contributor.authorYener, İsmail
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorTokul Ölmez, Özge
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorTekin, Fetullah
dc.contributor.authorHaşimi, Nesrin
dc.contributor.authorAlkan, Mehmet Hüseyin
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorErtaş, Abdulselam
dc.date.accessioned2020-02-18T07:00:44Z
dc.date.available2020-02-18T07:00:44Z
dc.date.issued2020-01-30en_US
dc.departmentBatman Üniversitesi Sağlık Yüksekokulu Beslenme ve Diyetetik Bölümüen_US
dc.description.abstractRepresentatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the chemical composition and biological activities of the essential oils obtained from sixteen Achillea species ( A. biebersteinii, A. wilhelmsii subsp. wilhelmsii, A.aleppica subsp. zederbaveri, A. vermicularis, A. monocephala, A. nobilis, A. goniocephala , A. sintenisii , A. coarctata, A. kotschyi subsp. kotschyi, A. millefolium subsp. millefolium, A. lycaonica, A. spinulifolia, A. teretifolia, A. setacea, and A. schischkinii ). Anticholinesterase, antiurease, antityrosinase enzymes inhibition, antioxidant, antimicrobial, toxic and cytotoxic activities of obtained essential oils were investigated. DPPH activities were found to be very low in all studied samples, while ABTS and CUPRAC antioxidant activities were found to be moderate. In addition, all samples were found to have moderate anticholinesterase and antimicrobial effects. It has been determined that the studied species have low cytotoxicity and high toxicity. Besides, chemical composition of the essential oils were determined by GC-MS and the results were chemometrically analyzed. The chemometric analyses of Achillea species collected from 9 different regions were accomplished by principal component analysis (PCA) and hierarchical cluster analysis (HCA) techniques. According to the PCA analysis, A. nobilis subsp. neilreichii was found to be different from all studied species in terms of essential oil composition. The major components found in these species were piperitone, camphor, α-terpinene, eucalyptol, artemisia-ketone, endo-borneol, β-eudesmol and verbenol. The fact that, camphor being toxic and found in majority of the studied species, stands out as a remarkable result.en_US
dc.identifier.citationYener, İ., Yılmaz, M. A., Ölmez, Ö. T., Akdeniz, M., Tekin, F., Haşimi, N., Ertaş, A. (2020). A detailed biological and chemical investigation of 16 Achillea species’ essential oils via chemometric approach. Chemistry & Biodiversity. https://doi.org/10.1002/cbdv.201900484en_US
dc.identifier.endpage14en_US
dc.identifier.issn1612-1880
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/epdf/10.1002/cbdv.201900484
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2377
dc.identifier.wosqualityN/Aen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.isversionof10.1002/cbdv.201900484en_US
dc.relation.journalChemistry & Biodiversityen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectAchilleaen_US
dc.subjectChemometric Approachen_US
dc.subjectBiological Activitiesen_US
dc.subjectEssential Oilen_US
dc.titleA detailed biological and chemical investigation of 16 Achillea species’ essential oilsvia chemometric approachen_US
dc.typeArticleen_US

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