New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode in the NaOH
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Indian Chemical Society
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Metformin(MET), an oral antidiabetic drug commonly used in the treatment of diabetes, is a
drug that increases insulin sensitivity in the biguanide group [1]. MET shows its
pharmacological effect by lowering the glucose level in the blood. In the literature research,
there are studies using electrochemical techniques for the analysis of MET in biological fluid
and drug forms[1-6]. In this study, the electrochemical properties of MET, one of the drugs
used in the treatment of diabetes, were performed using a pencil graphite electrode in NaOH
(0.1 M) solution. This compound was recorded with an irreversible and diffusion controlled
adsorption oxidation peak at approximately +1.28 V by cyclic voltammetry. With square
wave stripping voltammetry, it was observed that the peak current signals of MET in the
concentration range of 2.76-24.8 µM in 0.1M NaOH solution increased linearly. At a
concentration of 2.76 µM (n = 9), the limit of detection and relative standard deviation were
calculated as 9.03 nM (1.495 ngmL-1
) and 3.25 %, respectively. This method has been
successfully applied for MET analysis in pharmaceutical preparations and urine samples
without any separation.
Açıklama
Anahtar Kelimeler
Metformin, Voltammetry, Pencil Graphite Electrode, Drug, Urine
Kaynak
WoS Q Değeri
Q4
Scopus Q Değeri
Q4
Cilt
97
Sayı
1
Künye
Altunkaynak, Y., Yavuz, Ö., Levent, A. (2020). New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode in the NaOH. Journal of the Indian Chemical Society, 97 (1), pp. 1-12.
