New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode in the NaOH

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dc.authorid0000-0003-2562-9297en_US
dc.authorid0000-0002-7706-1878en_US
dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorAltunkaynak, Yalçın
dc.contributor.authorYavuz, Ömer
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2021-03-22T08:20:27Z
dc.date.available2021-03-22T08:20:27Z
dc.date.issued2020en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.departmentBatman Üniversitesi Teknik Bilimler Meslek Yüksekokulu Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractMetformin(MET), an oral antidiabetic drug commonly used in the treatment of diabetes, is a drug that increases insulin sensitivity in the biguanide group [1]. MET shows its pharmacological effect by lowering the glucose level in the blood. In the literature research, there are studies using electrochemical techniques for the analysis of MET in biological fluid and drug forms[1-6]. In this study, the electrochemical properties of MET, one of the drugs used in the treatment of diabetes, were performed using a pencil graphite electrode in NaOH (0.1 M) solution. This compound was recorded with an irreversible and diffusion controlled adsorption oxidation peak at approximately +1.28 V by cyclic voltammetry. With square wave stripping voltammetry, it was observed that the peak current signals of MET in the concentration range of 2.76-24.8 µM in 0.1M NaOH solution increased linearly. At a concentration of 2.76 µM (n = 9), the limit of detection and relative standard deviation were calculated as 9.03 nM (1.495 ngmL-1 ) and 3.25 %, respectively. This method has been successfully applied for MET analysis in pharmaceutical preparations and urine samples without any separation.en_US
dc.identifier.citationAltunkaynak, Y., Yavuz, Ö., Levent, A. (2020). New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode in the NaOH. Journal of the Indian Chemical Society, 97 (1), pp. 1-12.en_US
dc.identifier.endpage12en_US
dc.identifier.issn0019-4522
dc.identifier.issue1en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2744
dc.identifier.volume97en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherIndian Chemical Societyen_US
dc.relation.journalJournal of the Indian Chemical Societyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMetforminen_US
dc.subjectVoltammetryen_US
dc.subjectPencil Graphite Electrodeen_US
dc.subjectDrugen_US
dc.subjectUrineen_US
dc.titleNew voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode in the NaOHen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

Fen - Edebiyat Fakültesi, Kimya Bölümü, Makale Koleksiyonu
Batman Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, Makale Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu