Plantago major protective effects on antioxidant status after administration of 7,12-dimethylbenz(a)anthracene in rats
Küçük Resim Yok
Tarih
2011
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Asian Pacific Organization for Cancer Prevention
Erişim Hakkı
info:eu-repo/semantics/openAccess
Attribution-ShareAlike 3.0 United States
Attribution-ShareAlike 3.0 United States
Özet
Aim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p≤0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.
Açıklama
Anahtar Kelimeler
Antioxidant, DMBA, Lipid Peroxidation, Plantago Major, Rat
Kaynak
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
12
Sayı
2
Künye
Oto, G., Ekin, S., Özdemir, H., Demir, H., Yaşar, S., Levent, A., Berber, İ., Kaki, B. (2011). Plantago major protective effects on antioxidant status after administration of 7,12-dimethylbenz(a)anthracene in rats. Asian Pacific Journal of Cancer Prevention, 12 (2), pp. 531-535.
