Protective effect of Hypericum perforatum L. on serum and hair trace elements in rats 7,12-dimethylbenz[a]anthracene-induced oxidative stress
Yükleniyor...
Tarih
2012-02-08
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier
Erişim Hakkı
info:eu-repo/semantics/embargoedAccess
Attribution-NonCommercial-NoDerivs 3.0 United States
Attribution-NonCommercial-NoDerivs 3.0 United States
Özet
The study was designed to assess the effect of Hypericum perforatum L. (H.P) on serum and hair trace elements and mineral levels, oral administration of 7,12-dimethylbenz[a]anthracene (DMBA) induced oxidative stress in Sprague-Dawley female rats. Analysis of the trace element has been carried out using atomic absorption spectrophotometer method at end of 60th day. It has been found out that the DMBA group contained statistically lower Zn and Cr compared to the control group (p < 0.01) and (p < 0.05), Cu, Mg and Na contained higher than control group (p < 0.05), (p < 0.05) and (p < 0.05). In DMBA + H.P group, Zn higher and Na lower than DMBA group (p < 0.05), (p < 0.05), in hair samples Cd, K and Zn contained lower DMBA compared to the control group (p < 0.05), (p < 0.05) and (p < 0.05). In group DMBA + H.P, Cd was higher than DMBA group and Cr lowered accordance with control group (p < 0.05). The present study demonstrated significantly positive and beneficial effect of H.P on the concentration levels of Zn and Na in serum, also on Cd levels in hair between DMBA and DMBA + H.P groups.
Açıklama
Anahtar Kelimeler
Trace Element, DMBA, Hypericum Perforatum, Serum, Hair
Kaynak
WoS Q Değeri
Q2
Scopus Q Değeri
Q1
Q2
Q2
Cilt
33
Sayı
3
Künye
Ekin, S., Yardım, Y., Oto, G., Levent, A., Özgökçe, F., Kusman, T. (2012). Protective effect of Hypericum perforatum L. on serum and hair trace elements in rats 7,12-dimethylbenz[a]anthracene-induced oxidative stress. Environmental Toxicology and Pharmacology, 33 (3), pp. 440-445. https://doi.org/10.1016/j.etap.2012.01.010
