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Bölüm: Batman Üniversitesi Sağlık Hizmetleri Meslek Yüksekokulu Tıbbi Hizmetler ve Teknikler Bölümü × Dil: en ×

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Listeleniyor 1 - 10 / 21
  • Küçük Resim
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    The effects of cortistatin administration on plasma antioxidant system and cytokine levels of rabbits with acute inflammation
    (Batman Üniversitesi, 2017) Atalay, Banu
    In the study, it was aimed to research the effects of an endogenous neuropeptide called cortistatin (CST) which is isolated from the brain on parameters of antioxidant system and cytokine levels of rabbits with turpentine oil induced acute inflammation. In the study using 28 healthy, male rabbits from New Zealand breed, animals were randomly divided into four groups consisting of control (C), turpentine (T), cortistatin (250 µg/kg) (CST), and turpentine + cortistatin (250 µg/kg) (T+CST). Reduced glutathione (GSH), super oxide dismutase (SOD, malondialdehyde (MDA) levels belonging to antioxidant and oxidant systems, interleukin-6 (IL-6) and tumor necrosis factor -α (TNF-α) levels from inflammatory cytokines were studied in the blood samples taken after 2 and 6 hours and while cortistatin administration significantly contributed for maintaining GSH at protective level in T+CST group (p<0.05), it caused a change which was not statistically significant with respect to MDA and SOD levels increasing based on elevated lipid peroxidation levels in the tissue along with the inflammation (p>0.05). Depending on resulting data of the study, it was concluded that despite there were effects observed regarding that cortistatin plays an inflammation suppressing role, this was smaller than the effect observed in conditions such as endotoxemia and sepsis because design of study did not lasted for long.
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    Predicting factors affecting PISA 2015 mathematics literacy via radial basis function artificial neural network
    (Batman Üniversitesi, 2019-05-23) Güre Bezek, Özlem; Kayri, Murat; Erdoğan, Fevzi
    In this study, radial basis function artificial neural network (RBFN), which is one of the of data mining methods, was employed to determine the factors affecting PISA 2015 (Programme for International Student Assessment - PISA), Mathematics literacy. Mathematics literacy scores, which were made in categorical form with three level dependent variables, 25 independent variables, and considered to have affected the dependent variables, were employed in evaluating and validating the proposed method. Also, in order to determine factors affecting PISA 2015 Mathematics literacy, information obtained from a total of 4422 students (2165 (49%) of whom were males and 2257 (51%) of whom were females) who participated the exam was used. According to the obtained results, the correct classification rate of mathematics achievement in the radial based artificial neural network model was found to be 85.2%. In addition, it is seen that the most important factor that were affecting Mathematics literacy was Turkish language success status and the other variables that were setting significance are targeted point in school life, father education level and mother education level.
  • Küçük Resim Yok
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    Control of barrier heigth ofmetal/semiconductor contacts bymolecular organic film
    (2011-06) Güllü, Ömer; Turut, Abdulmecit; Kılıçoğlu, Tahsin; Özerden, Enise
  • Küçük Resim Yok
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    Characterization of Au N Inp photovoltaic structure with organic thin film
    (Uppsala University, 2012) Güllü, Ömer; Özerden, Enise; Rüzgar, Şerif; Asubay, Sezai; Pakma, Osman; Kılıçoğlu, Tahsin; Türüt, Abdulmecit
  • Küçük Resim Yok
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    New schiff base ligand derived from 4-aminoantipyrine: Synthesis and spectroscopic characterization
    (Azərbaycan Dövlət Neft və Sənaye Universiteti, 2017) Dağ, Beşir; Yaşar, Fevzi; Çakmak, Reşit
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    Design, preparation and application of a Pirkle-type chiral stationary phase for enantioseparation of some racemic organic acids and molecular dynamics studies
    (ACG Publications, 2017-11) Çakmak, Reşit; Ercan, Selami; Sünkür, Murat; Yılmaz, Hayrullah; Topal, Giray
    This study consists of two parts. In the first part of the study; a Pirkle-type chiral stationary phase was prepared by synthesizing an aromatic amine derivative of (R)-2-amino-1-butanol as a chiral selector and binding to L-tyrosine-modified cyanogen bromide (CNBr)-activated Sepharose 4B and then, packed into the separation column. The chromatographic performance of the separation column was evaluated with racemic mandelic acid and 2-phenylpropionic acid by using phosphate buffers at three different pHs as mobile phase. In the resolution processes, the prepared solutions were loaded onto the separation column at two different concentrations and at three different pHs for each racemic organic acid, separately. Enantiomeric excess (ee%) of the eluates was determined on CHIRALPAK AD-H chiral analytical column by HPLC. The maximum ee% for mandelic acid and 2-phenylpropionic acid was determined to be 60.84 and 27.4, respectively. Separation factors (k1 ’ , k2 ’ , α, and Rs) were calculated for each acid. The structures of the obtained compounds were characterized using the spectroscopic methods (NMR, and elemental analysis). In the second part of the study; enantioselective interactions between the prepared CSP and the analytes have been widely studied by docking, molecular dynamics simulation and quantum mechanical computation methods. The reason of column eluation of rac-2-phenylpropionic acid with lower enantiomeric yield was explained by these techniques.
  • Küçük Resim
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    Synthesis and anticorrosion studies of 4-[(2-nitroacetophenonylidene)-amino]-antipyrine on SAE 1012 carbon steel in 15 wt.% HCl solution
    (Taylor & Francis, 2020-11-16) Gerengi, Hüsnü; Çakmak, Reşit; Dağ, Beşir; Solomon, M. M; Tüysüz Akbal, Hatice Aslıhan; Kaya, Ertuğrul
    A novel corrosion inhibitor, ((E)-1,5-dimethyl-4-((1-(3-nitrophenyl)ethylidene)amino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) (DNPP) was synthesized in high yield by the condensation reaction of 4-aminoantipyrine with 2-nitroacetphenone derived from acetophenone as a starting material and characterized by FT-IR, 1H, and 13C NMR techniques. DNPP was tested against the corrosion of SAE 1012 carbon steel in 15 wt.% HCl solution using electrochemical and surface characterization techniques. Results obtained show that DNPP is effective in retarding the corrosion of SAE 1012 carbon steel. With 4 mM of DNPP, the charge transfer resistance of SAE 1012 in 15 wt.% HCl solution is raised from 17.42 to 140.50 Ω cm2 and the substrate surface is protected by 87%. The inhibition is through adsorption mechanism (mixed-adsorption type) and has been confirmed by SEM and EDAX results. Potentiodynamic polarization results reveal that DNPP acted as a mixed-type corrosion inhibitor. DNPP is a promising candidate for the formulation of an inhibitor cocktail for the strong acid environment.
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  • Küçük Resim Yok
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    Electroanalytical investigation of antineoplastic drug vinorelbine at pencil graphite electrode in surfactant media
    (Turkish Chemical Society, 2019) Önal, Günay; Levent, Abdulkadir; Şentürk, Zühre
    Vinorelbine (sold under the brand name Navelbine), one of the semisynthetic derivatives of Vinca alkaloids, has been widely used either alone or in combination with other drugs in the tre- atment of leukemia, lymphoma, advanced testicular cancer and Kaposi's sarcoma. From the electrochemical point of view, only one study that was quite old has been reported on its voltammetric characteris- tics so far (Brett et al.). Keeping the above knowledge in mind, in the present study, a novel application of single-use pencil graphite (PG) electrode is introduced for the determination of Vinorelbine. The electrochemical oxidation of this compound was first investigated by cyclic voltammetry in aqueous solutions. Special attention was given to the use of adsorptive stripping vol- tammetry at a surface of PG electrode and glassy carbon (GC) one (for comparison purpose) in aqueous solutions over the pH range of 2.0-12.0 both without and with the addition of different charged surfactants. The sensitivity of the stripping voltammet- ric measurements was significantly improved when the anionic (sodium dodecylsulfate, SDS) and cationic (tetra-n-butylammo- nium bromide, TBAB) surfactants were present in the Vinorelbi- ne-containing electrolyte solution at pH 2.0-4.0 and pH 9.0-10.0, respectively, by using PG electrode. Using square-wave stripping mode, Vinorelbine yielded a well-defined voltammetric response in Britton-Robinson buffer pH 10.0 containing 3×10−3 M TBAB at +0.75 V (vs. Ag/AgCl) (after 120 s accumulation at +0.0 V). The process could be used to determine this compound in the concentration range of 2.3×10−8 – 5.8×10−6 M, with a detection limit of 7.5×10−9 M (base-5.8 ng mL1−). The proposed method was successfully applied to pharmaceutical formulations and the spiked human urine samples.
  • Küçük Resim Yok
    Öğe
    Simultaneous electrochemical evaluation of ascorbic acid, epinephrine and uric acid at disposable pencil graphite electrode: Highly sensitive determination in pharmaceuticals and biological liquids by differential pulse voltammetry
    (Elsevier, 2018) Levent, Abdulkadir; Önal, Günay
    Aim and Objective: As is known, AA, EP and UA can also coexist in biological fluids. Therefore, the determination of the levels of these compounds in biological fluids is extremely important both for the diagnosis and treatment of the related diseases. In the presence of many interfering substances in biological fluids such as blood and urine samples, it is very important that these compounds can be selectively analyzed. Materials and Methods: All electrochemical experiments were performed using an Autolab PGSTAT 128N potentiostat. Before beginning the electrochemical measurements, the PGE was activated. The electrochemical pretreatment of PG was exercised by anodically +1.40 V for 60 s. Then, measurements were performed with CV (-0.4 V to 1.2 V) and DPV (-0.2 V to 0.7 V) for single and simultaneous voltammetric behaviour of AA, EP, and UA in the electrochemical method. Results: The anodic peak potentials of AA and UA were observed at about +0.32 V and +0.62 V, respectively. On the other hand, for EP, while anodic peak potential was observed at about +0.53 V, in the reverse scan, cathodic peak potentials were observed at about +0.41 V and +0.007 V. The39 reduction peak observed at +0.3 V with the oxidation peak observed at +0.53 V are the reversible peaks. In the method developed for the electrochemical simultaneous determination of AA, EP and UA using PGE with DPV technique in BR buffer solution (pH 4.0), the anodic peak potentials are sufficiently separated from each other. Conclusion: A voltammetric method was developed for the simultaneous determination of AA, EP and UA with PGE for the first time. Here, the most important thing is that the simultaneous determination of AA, EP and UA was successfully achieved with that targeted voltammetric method which was sensitive, low-cost, practical and well-repeated; and that these were proven to be selectively applicable in pharmaceutical products and biological liquids.