Electroanalytical investigation of antineoplastic drug vinorelbine at pencil graphite electrode in surfactant media
Küçük Resim Yok
Tarih
2019
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Yayıncı
Turkish Chemical Society
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Vinorelbine (sold under the brand name Navelbine), one of
the semisynthetic derivatives of Vinca alkaloids, has been widely
used either alone or in combination with other drugs in the tre-
atment of leukemia, lymphoma, advanced testicular cancer and
Kaposi's sarcoma.
From the electrochemical point of view, only one study that
was quite old has been reported on its voltammetric characteris-
tics so far (Brett et al.). Keeping the above knowledge in mind,
in the present study, a novel application of single-use pencil
graphite (PG) electrode is introduced for the determination of
Vinorelbine. The electrochemical oxidation of this compound
was first investigated by cyclic voltammetry in aqueous solutions.
Special attention was given to the use of adsorptive stripping vol-
tammetry at a surface of PG electrode and glassy carbon (GC)
one (for comparison purpose) in aqueous solutions over the pH
range of 2.0-12.0 both without and with the addition of different
charged surfactants. The sensitivity of the stripping voltammet-
ric measurements was significantly improved when the anionic
(sodium dodecylsulfate, SDS) and cationic (tetra-n-butylammo-
nium bromide, TBAB) surfactants were present in the Vinorelbi-
ne-containing electrolyte solution at pH 2.0-4.0 and pH 9.0-10.0,
respectively, by using PG electrode. Using square-wave stripping
mode, Vinorelbine yielded a well-defined voltammetric response
in Britton-Robinson buffer pH 10.0 containing 3×10−3 M TBAB
at +0.75 V (vs. Ag/AgCl) (after 120 s accumulation at +0.0 V).
The process could be used to determine this compound in the
concentration range of 2.3×10−8 – 5.8×10−6 M, with a detection
limit of 7.5×10−9 M (base-5.8 ng mL1−). The proposed method
was successfully applied to pharmaceutical formulations and the
spiked human urine samples.
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Künye
Önal, G., Şentürk, Z., Levent, A. (2019). Electroanalytical investigation of antineoplastic drug vinorelbine at pencil graphite electrode in surfactant media. XX. Euroanalysis Conference, 1-5 September 2019, İstanbul.
