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Öğe Do low serum uch-l1 and tdp-43 levels indicate disturbed ubiquitin- proteosome system in autism spectrum disorder?(Türk Nöropsikiyatri Derneği, 2017) Çetin, İhsan; Tezdiğ, İhsan; Tarakçıoğlu, Mahmut Cem; Kadak, Muhammed Tayyib; Demirel, Ömer Faruk; Erdoğan, Fırat; Doğangün, BurakIntroduction: The mechanism of ubiquitination-related abnormalities causing neural development problems is still unclear. We examined the association between autism and serum transactive response DNAbinding protein-43 (TDP-43) and ubiquitin c-terminal hydrolase-L1 (UCH-L1) levels, both of which are members of the ubiquitinproteosome system. Methods: We measured serum levels of TDP-43 and UCH-L1 in 24 children with autism and 24 healthy children. Childhood Autism Rating Scale (CARS) was used to assess symptom severity at admission. Results: The mean serum TDP-43 and UCH-L1 levels in children with autism spectrum disorder (ASD) were found to decrease compared to healthy controls (p<0.001, 506.21±780.97 ng/L and 1245.80±996.76 ng/L, respectively; 3.08±5.44 ng/mL and 8.64±6.67 ng/mL, respectively). A positive correlation between serum TDP-43 levels and UCH-L1 levels was found in the ASD group (r=0.947, n=24, p<0.001). The CARS score of children with ASD was 48.91 points (standard deviation [SD]: 5.82). Conclusion: Low serum levels of UCH-L1 and TDP-43 may reflect disturbed ubiquitination in autism.Öğe Correlation of nutritional element levels in drinking water with body compositions of women aged 55-70 years living in Batman province(Dicle Üniversitesi, 2017-02-02) Çetin, İhsan; Nalbantçılar, Tahir; Güler Saban, Meryem; İnci, Ramazan; Tosun, Kezban; Nazik, AydanObjective: A growing interest in cellular targets of nutritional minerals and biochemical mechanisms has attracted the attentions of researchers towards their role in formation of obesity. However, there is no study investigating the effects of nutritional element levels of drinking water on body composition of the elderly. Therefore, we aimed to examine the effects of nutritional element levels in drinking water on body composition of women aged 55-70. Methods: The study population consisted of 80 participants in total, and was divided into three groups as overweight, obese and control women aged between 55-70. The bioelectric impedance device was used for measurements of body composition of the participants. Iron (Fe), copper (Cu), cobalt (Co), zinc (Zn), manganese (Mn) and selenium (Se) levels of drinking water were measured via plasma mass spectrometry coupled inductively. Results: It was found that Se mineral content in drinking water correlated with the body mass index of the individuals living in Batman, Turkey. Moreover, it was found that Fe, Cu, Co, Zn, Mn and Se levels of drinking water significantly correlated with the abdominal adiposity of women of 55-70. Conclusion: It may be suggested that the obesity risk may be higher in women who are between 55-70 and consume drinking water with high levels of Fe, Cu, Co, Zn, Mn and especially Se.
