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Öğe Synthesis, characterization and experimental, theoretical, electrochemical, antioxidant and antibacterial study of a new Schiff base and its complexes(Elsevier, 2014-09-15) Baykara, Hacı; İlhan, Salih; Levent, Abdulkadir; Seyitoğlu, Mehmet Salih; Özdemir, Sadin; Okumuş, Veysi; Öztomsuk, Abdussamet; Cornejo, MauricioA new Schiff base ligand was synthesized by reaction of salicylaldehyde with 1,6-bis(4-chloro-2-aminophenoxy)hexane. Then the Schiff base complexes were synthesized by metal salts and the Schiff base. The metal to ligand ratio of metal complexes was found to be 1:1. The Cu(II) complex is proposed to be square planar and the Co(II), Ni(II), Mn(II) and Zn(II) complexes are proposed to be tetrahedral geometry. The Ti(III) and V(III) complexes are proposed to be a capped octahedron in which a seventh ligand has been added to triangular face. The complexes are non-electrolytes as shown by their molar conductivities (ΛM). The structure of metal complexes is proposed from elemental analysis, FT-IR, UV–vis, magnetic susceptibility measurements, molar conductivity measurements, Mass Spectra and thermal gravimetric analysis. In addition antimicrobial and antioxidant studies, cyclic voltammetry of the complexes, theoretical 1H NMR and HOMO–LUMO energy calculations of the new di-functional ligand were done.Öğe A detailed biological and chemical investigation of 16 Achillea species’ essential oilsvia chemometric approach(Wiley-Blackwell, 2020-01-30) Yener, İsmail; Yılmaz, Mustafa Abdullah; Tokul Ölmez, Özge; Akdeniz, Mehmet; Tekin, Fetullah; Haşimi, Nesrin; Alkan, Mehmet Hüseyin; Öztürk, Mehmet; Ertaş, AbdulselamRepresentatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the chemical composition and biological activities of the essential oils obtained from sixteen Achillea species ( A. biebersteinii, A. wilhelmsii subsp. wilhelmsii, A.aleppica subsp. zederbaveri, A. vermicularis, A. monocephala, A. nobilis, A. goniocephala , A. sintenisii , A. coarctata, A. kotschyi subsp. kotschyi, A. millefolium subsp. millefolium, A. lycaonica, A. spinulifolia, A. teretifolia, A. setacea, and A. schischkinii ). Anticholinesterase, antiurease, antityrosinase enzymes inhibition, antioxidant, antimicrobial, toxic and cytotoxic activities of obtained essential oils were investigated. DPPH activities were found to be very low in all studied samples, while ABTS and CUPRAC antioxidant activities were found to be moderate. In addition, all samples were found to have moderate anticholinesterase and antimicrobial effects. It has been determined that the studied species have low cytotoxicity and high toxicity. Besides, chemical composition of the essential oils were determined by GC-MS and the results were chemometrically analyzed. The chemometric analyses of Achillea species collected from 9 different regions were accomplished by principal component analysis (PCA) and hierarchical cluster analysis (HCA) techniques. According to the PCA analysis, A. nobilis subsp. neilreichii was found to be different from all studied species in terms of essential oil composition. The major components found in these species were piperitone, camphor, α-terpinene, eucalyptol, artemisia-ketone, endo-borneol, β-eudesmol and verbenol. The fact that, camphor being toxic and found in majority of the studied species, stands out as a remarkable result.
