New voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode
Küçük Resim Yok
Tarih
2020
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ICNTC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Attribution-NonCommercial-NoDerivs 3.0 United States
Attribution-NonCommercial-NoDerivs 3.0 United States
Özet
Various drugs made of metal compounds have been used in many diseases including
cancer[1]. Studies on Oxaliplatin in the literature are these [2-6]. Oxaliplatin (OxPt), which is
a platinum analogue with anti-cancer effect, was accentuated. OxPt is separated from
cisplatin, one of analogues of platinum, by replacing 1,2-diaminocyclohexane with amine
groups. In this study, a simple, fast and sensitive voltammetric method was developed for
OxPt which shows anticancer effects with cytotoxic properties. The boron-doped diamond
(BDD) electrode was activated electrochemically in cathodic direction in 0.5 M H2SO4
medium. Electrochemical properties of OxPt were investigated on BDD electrode surface
using square-wave and cyclic voltammetry techniques. OxPt in Britton-Robinson(BR) buffer
(pH 5.0) gave a well-determined voltammetric response at +1.01 V (vs. Ag/AgCl) using the
square-wave voltammetry technique. The developed voltammetric technique was found to be
linear with the concentration range of 1.0-3.5 μM in the BR (pH 5.0) medium and the limit of
detection was 0.276 μM (0.109 μg mL-1
). Recommended method was successfully applied to
drug forms of OxPt.
Açıklama
Anahtar Kelimeler
Oxalipaltin, Boron-Doped Diamond, Voltammetry
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Aslan, M., Levent, A. (2020). New voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.
