New voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode

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dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorAslan, Mehmet
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2021-03-24T11:53:45Z
dc.date.available2021-03-24T11:53:45Z
dc.date.issued2020en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.description.abstractVarious drugs made of metal compounds have been used in many diseases including cancer[1]. Studies on Oxaliplatin in the literature are these [2-6]. Oxaliplatin (OxPt), which is a platinum analogue with anti-cancer effect, was accentuated. OxPt is separated from cisplatin, one of analogues of platinum, by replacing 1,2-diaminocyclohexane with amine groups. In this study, a simple, fast and sensitive voltammetric method was developed for OxPt which shows anticancer effects with cytotoxic properties. The boron-doped diamond (BDD) electrode was activated electrochemically in cathodic direction in 0.5 M H2SO4 medium. Electrochemical properties of OxPt were investigated on BDD electrode surface using square-wave and cyclic voltammetry techniques. OxPt in Britton-Robinson(BR) buffer (pH 5.0) gave a well-determined voltammetric response at +1.01 V (vs. Ag/AgCl) using the square-wave voltammetry technique. The developed voltammetric technique was found to be linear with the concentration range of 1.0-3.5 μM in the BR (pH 5.0) medium and the limit of detection was 0.276 μM (0.109 μg mL-1 ). Recommended method was successfully applied to drug forms of OxPt.en_US
dc.identifier.citationAslan, M., Levent, A. (2020). New voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrode. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.en_US
dc.identifier.isbn9786056747656
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2790
dc.language.isoenen_US
dc.publisherICNTCen_US
dc.relation.journal6th International Conference on New Trends in Chemistry, 17-18 October 2020en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subjectOxalipaltinen_US
dc.subjectBoron-Doped Diamonden_US
dc.subjectVoltammetryen_US
dc.titleNew voltammetric method for determination and electrochemical behaviors of oxaliplatin by CPT-BDD electrodeen_US
dc.typeConference Objecten_US

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