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Öğe Geothermal water potential of Bursa (Turkey) province(Scholars Middle East Publishers, 2017-12) Dağ, Beşir; Bilgin, AliÖğe New drug loading systems: Using two component gelling strategy(Ankara Üniversitesi, 2015) Çolak, Mehmet; Evcil, Murat; Barış Cebe, Deniz; Hoşgören, HalilÖğe The changes in the serum, liver, kidney protein and genomic DNA profiles in rats treated with 7,12-Dimethylbenz(A) anthracene and Plantago major L.(RJPBCS, 2014-01) Berber, İsmet; Ekin, Suat; Levent, Abdulkadir; Oto, Gökhan;In the study, the changes in the serum, liver, kidney protein and genomic DNA profiles in Wistar albino rats administrated to 7,12-dimethylbenz(a)anthracene (DMBA) and Plantagomajor L. were investigated. SDS-PAGE profiling of the serum proteins showed that the levels of two proteins molecular weighing 140.8 kDa and 46.8 kDa were significantly lower on the 0th day of treatment than on the 60th day of application in the groups. Furthermore, two proteins (34.5 and 22.3 kDa) were solely present in DMBA-treated liver cell lysates. On the contrary, the kidney protein profiles did not show significant banding variations in groups. Genomic DNA analysis also confirmed that DNA extracted from liver and kidney cells did not fragment in any of the groups after the 60th study day. The proteins 34.5 and 22.3 kDa in liver cell lysates at the 60th day in DMBA-treated group could be extra-prognostic indicators for severe DMBA toxicity.Öğe Effective adsorption of Co(II) ions from synthesized nano-adsorbent (Fe3O4/SiO2/Aptes/Pamam(G2)/Mu)(2019-05) Ekinci, Selma; İlter, ZülfiyeÖğe Kiral tetraamid jelatörleri(Erzurum Atatürk Üniversitesi, 2018-03) Aral, Tarık; Aral, Hayriye; Sünkür, Murat; Barış Cebe, DenizÖğe New voltammetric strategy for determination and electrochemical behaviors of metformin by pencil graphite electrode in the NaOH(Indian Chemical Society, 2020) Altunkaynak, Yalçın; Yavuz, Ömer; Levent, AbdulkadirMetformin(MET), an oral antidiabetic drug commonly used in the treatment of diabetes, is a drug that increases insulin sensitivity in the biguanide group [1]. MET shows its pharmacological effect by lowering the glucose level in the blood. In the literature research, there are studies using electrochemical techniques for the analysis of MET in biological fluid and drug forms[1-6]. In this study, the electrochemical properties of MET, one of the drugs used in the treatment of diabetes, were performed using a pencil graphite electrode in NaOH (0.1 M) solution. This compound was recorded with an irreversible and diffusion controlled adsorption oxidation peak at approximately +1.28 V by cyclic voltammetry. With square wave stripping voltammetry, it was observed that the peak current signals of MET in the concentration range of 2.76-24.8 µM in 0.1M NaOH solution increased linearly. At a concentration of 2.76 µM (n = 9), the limit of detection and relative standard deviation were calculated as 9.03 nM (1.495 ngmL-1 ) and 3.25 %, respectively. This method has been successfully applied for MET analysis in pharmaceutical preparations and urine samples without any separation.Öğe Synthesis and characterization of hydrogen bonded 4-octyloxy benzoic acid/sebacic acid binary liquid crystal complex(Bitlis Eren Üniversitesi, 2017) Okumuş, Mustafa; Sünkür, MuratIn this study, the binary liquid crystal complex system was synthesized from mesogenic 4-octyloxy benzoic acid (8BAO) and non-mesogenic sebacic acid (SEA) chemical compounds. The thermal and microstructural properties of the synthesized 8BAO/SEA binary liquid crystal complex system were investigated by differential scanning calorimeter (DSC) and polarized optical microscopy (POM). The formation of the hydrogen bond between the 8BAO and SEA compounds was confirmed by Fourier Transformed Infrared spectroscopy (FTIR) assays. The DSC and POM results showed that the 8BAO/SEA binary complex exhibited liquid crystalline properties due to the hydrogen bonds formed. The 8BAO/SEA binary liquid crystal complex showed four phase transition peak indicating Cr↔SmG↔SmC↔N↔I phase sequence during continuous heating and cooling by DSC. This phase sequence has also been confirmed by POM observations. Furthermore, the effect of the heating rate on the phase transition temperature and enthalpy change values was investigated, and as the heating rate increased, the phase transition temperature and enthalpy values generally increased. Additionally, the thermal stability factor and the phase transition order parameter were calculated and the phase transitions were found to be regular.Öğe Syntheses of c2 symmetrical chiral tetraamides and their enantiomeric recognition ablity towards amino acide esthers(EJONS International Congress on Mathematics, Enginerimg and Natural Science, 2018-04) Aral, Tarık; Sünkür, Murat; Barış Cebe, Deniz; Aral, HayriyeÖğe Plantago major protective effects on antioxidant status after administration of 7,12-dimethylbenz(a)anthracene in rats(Asian Pacific Organization for Cancer Prevention, 2011) Oto, Gökhan; Ekin, Suat; Özdemir, Hülya; Demir, Halit; Yaşar, Semih; Levent, Abdulkadir; Berber, İsmet; Kaki, BarışAim: The present study was designed to evaluate effects of Plantago major extract on oxidative status in Wistar albino rats administrated 7,12-dimethylbenz(a)anthracene (DMBA). Methods: Rats were divided into three equal groups of 6 animals each: Group 1 controls, group 2 treated with DMBA (100 mg/kg, single dose) and group 3 receiving the DMBA and the aqueous extract at 100 mg/kg/d for 60 days. Results: Significant decrease in catalase (P<0.05), carbonic anhydrase (p≤0.01), reduced glutathione (GSH) (P<0.01) and total protein (P<0.01) values was observed in the DMBA group compared with the healthy controls and DMBA + Plantago major groups. Conclusion: The results suggest preventive effects of Plantago major on DMBA induced oxidative damage in Wistar albino rats that might be due to decreased free radical generation.Öğe İmin Temelli C2-simetrik bis(fosfinit)-Ru(II) kompleksinin sentezi ve asimetrik transfer hidrojenasyon reaksiyonlarındaki etkinliği(Burdur Mehmet Akif Ersoy Üniversitesi, 2017) Elma Karakaş, Duygu; Saleh, Najmuldain Abdullah; Sünkür, Murat; Baysal, Akın; Aydemir, Murat; Durap, Feyyaz
