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Öğe The effects of cortistatin administration on plasma antioxidant system and cytokine levels of rabbits with acute inflammation(Batman Üniversitesi, 2017) Atalay, BanuIn the study, it was aimed to research the effects of an endogenous neuropeptide called cortistatin (CST) which is isolated from the brain on parameters of antioxidant system and cytokine levels of rabbits with turpentine oil induced acute inflammation. In the study using 28 healthy, male rabbits from New Zealand breed, animals were randomly divided into four groups consisting of control (C), turpentine (T), cortistatin (250 µg/kg) (CST), and turpentine + cortistatin (250 µg/kg) (T+CST). Reduced glutathione (GSH), super oxide dismutase (SOD, malondialdehyde (MDA) levels belonging to antioxidant and oxidant systems, interleukin-6 (IL-6) and tumor necrosis factor -α (TNF-α) levels from inflammatory cytokines were studied in the blood samples taken after 2 and 6 hours and while cortistatin administration significantly contributed for maintaining GSH at protective level in T+CST group (p<0.05), it caused a change which was not statistically significant with respect to MDA and SOD levels increasing based on elevated lipid peroxidation levels in the tissue along with the inflammation (p>0.05). Depending on resulting data of the study, it was concluded that despite there were effects observed regarding that cortistatin plays an inflammation suppressing role, this was smaller than the effect observed in conditions such as endotoxemia and sepsis because design of study did not lasted for long.Öğe Predicting factors affecting PISA 2015 mathematics literacy via radial basis function artificial neural network(Batman Üniversitesi, 2019-05-23) Güre Bezek, Özlem; Kayri, Murat; Erdoğan, FevziIn this study, radial basis function artificial neural network (RBFN), which is one of the of data mining methods, was employed to determine the factors affecting PISA 2015 (Programme for International Student Assessment - PISA), Mathematics literacy. Mathematics literacy scores, which were made in categorical form with three level dependent variables, 25 independent variables, and considered to have affected the dependent variables, were employed in evaluating and validating the proposed method. Also, in order to determine factors affecting PISA 2015 Mathematics literacy, information obtained from a total of 4422 students (2165 (49%) of whom were males and 2257 (51%) of whom were females) who participated the exam was used. According to the obtained results, the correct classification rate of mathematics achievement in the radial based artificial neural network model was found to be 85.2%. In addition, it is seen that the most important factor that were affecting Mathematics literacy was Turkish language success status and the other variables that were setting significance are targeted point in school life, father education level and mother education level.Öğe Benzoil ester grubu içeren 2,4-dinitrofenilhidrazin temelli bazı yeni hidrazon bileşiklerinin sentezi ve yapısal karakterizasyonu(Batman Üniversitesi, 2022-06-30) Çakmak, Reşit; Başaran, EyüpHidrazon bileşikleri, ilaç tasarımı çalışmalarında aday bileşikleri elde etmek için kullanılan önemli öncülerdir. Bu çalışmada, başlangıç materyali olarak 4-(dietilamino) salisilaldehitten türetilen benzoil ester türevleri (1-5) sübstitüe benzoil klorür türevleri (benzoil klorür, 2-nitrobenzoil klorür, 3-nitrobenzoil klorür, 4-nitrobenzoil klorür ve 3,5-dinitrobenzoil klorür) ile çözücü olarak piridin ortamında 1:1 mol oranında reaksiyona girmesiyle sentezlendi. Elde edilen benzoil esterler ile 2,4-dinitrofenilhidrazinin kondenzasyon reaksiyonu ile yeni bir dizi hidrazon bileşikleri (6-10) sentezlendi ve bu bileşikler yapısal karakterizasyonu FT-IR, 1H NMR, 13C NMR ve element analizi aydınlatıldı. Sonuç olarak, bu bileşiklerin biyolojik aktiviteler gösterebileceği düşünülmektedir.Öğe Design, preparation and application of a Pirkle-type chiral stationary phase for enantioseparation of some racemic organic acids and molecular dynamics studies(ACG Publications, 2017-11) Çakmak, Reşit; Ercan, Selami; Sünkür, Murat; Yılmaz, Hayrullah; Topal, GirayThis study consists of two parts. In the first part of the study; a Pirkle-type chiral stationary phase was prepared by synthesizing an aromatic amine derivative of (R)-2-amino-1-butanol as a chiral selector and binding to L-tyrosine-modified cyanogen bromide (CNBr)-activated Sepharose 4B and then, packed into the separation column. The chromatographic performance of the separation column was evaluated with racemic mandelic acid and 2-phenylpropionic acid by using phosphate buffers at three different pHs as mobile phase. In the resolution processes, the prepared solutions were loaded onto the separation column at two different concentrations and at three different pHs for each racemic organic acid, separately. Enantiomeric excess (ee%) of the eluates was determined on CHIRALPAK AD-H chiral analytical column by HPLC. The maximum ee% for mandelic acid and 2-phenylpropionic acid was determined to be 60.84 and 27.4, respectively. Separation factors (k1 ’ , k2 ’ , α, and Rs) were calculated for each acid. The structures of the obtained compounds were characterized using the spectroscopic methods (NMR, and elemental analysis). In the second part of the study; enantioselective interactions between the prepared CSP and the analytes have been widely studied by docking, molecular dynamics simulation and quantum mechanical computation methods. The reason of column eluation of rac-2-phenylpropionic acid with lower enantiomeric yield was explained by these techniques.Öğe Synthesis and anticorrosion studies of 4-[(2-nitroacetophenonylidene)-amino]-antipyrine on SAE 1012 carbon steel in 15 wt.% HCl solution(Taylor & Francis, 2020-11-16) Gerengi, Hüsnü; Çakmak, Reşit; Dağ, Beşir; Solomon, M. M; Tüysüz Akbal, Hatice Aslıhan; Kaya, ErtuğrulA novel corrosion inhibitor, ((E)-1,5-dimethyl-4-((1-(3-nitrophenyl)ethylidene)amino)-2-phenyl-1,2-dihydro-3H-pyrazol-3-one) (DNPP) was synthesized in high yield by the condensation reaction of 4-aminoantipyrine with 2-nitroacetphenone derived from acetophenone as a starting material and characterized by FT-IR, 1H, and 13C NMR techniques. DNPP was tested against the corrosion of SAE 1012 carbon steel in 15 wt.% HCl solution using electrochemical and surface characterization techniques. Results obtained show that DNPP is effective in retarding the corrosion of SAE 1012 carbon steel. With 4 mM of DNPP, the charge transfer resistance of SAE 1012 in 15 wt.% HCl solution is raised from 17.42 to 140.50 Ω cm2 and the substrate surface is protected by 87%. The inhibition is through adsorption mechanism (mixed-adsorption type) and has been confirmed by SEM and EDAX results. Potentiodynamic polarization results reveal that DNPP acted as a mixed-type corrosion inhibitor. DNPP is a promising candidate for the formulation of an inhibitor cocktail for the strong acid environment.Öğe Application of a pencil graphite electrode for voltammetric simultaneous determination of ascorbic acid, norepinephrine, and uric acid in real samples(TÜBİTAK, 2018-04-27) Levent, Abdulkadir; Önal, GünayA pencil graphite electrode (PGE) was used for the simultaneous detection of ascorbic acid (AA), norepinephrine (NE), and uric acid (UA) by differential pulse voltammetry and cyclic voltammetry. The anodic peaks of AA, NE, and UA in their mixture can be well separated in 0.1 M Britton–Robinson buffer solution at pH 4.0. The effects of various experimental parameters such as pH, scan rate, and voltammetric parameters on the voltammetric response of these compounds were investigated. Under optimum conditions, linear calibration graphs were obtained from the AA, NE, and UA concentration ranges, which were 100–800 nM, 20–170 nM, and 40–175 nM, respectively. The detection limits for AA, NE, and UA were 27 nM, 4 nM, and 10 nM in the form of a mixture at the PGE. This electrode shows great analytical performance characteristics, corresponding repeatability and recovery for the simultaneous determination of these compounds. PGE, which was used for the first time in this method, has been successfully applied for the assay of UA in human urine samples with the aim of determining AA and NE in pharmaceutical drugs.Öğe The methods used in histopathological evaluation of testis tissues(Batman Üniversitesi, 2020-06-30) Yalçın, Tuba; Kaya, Sercan; Kaya Tektemur, Nalan; Ozan, İ. EnverThe quantitative measurements are numerical data as the outputs of various processes. Statistical analysis is employed to the collected data. Results obtained from the statistical data are considered as more reliable. Therefore, measurement processes are the basis of research sciences today. Histology is a discipline that examines the microscopic structure of cells and tissues. Morphometric measurements can be performed on cell and tissue samples through electron and light microscope. In the PubMed search engine, MEDLINE, SCIENCE DIRECT and Web of Science, Springer Link, and Ovid were scanned for the words “Testis, histopathology, quantitative, seminiferous tubule”. The findings obtained through these qualitative methods provide interpretation of the changes in tissue morphology. These assessments allow researchers to identify the tissue samples and to compare the physiological variations in its morphology. In histology, the results obtained from routine dyeing of laboratory studies are qualitative, therefore, relative differences may emerge in the interpretation of the results. In order to eliminate this risk, various quantitative measurement methods are implemented. Today, in order to employ accurate evaluations, the histometric and stereological measurement methods that are used in organs such as testicles, liver, lung, and kidney gain importance. The quantitative data obtained from these transactions is sufficient for statistical analysis. It is also important to reach a certain standardization level in the repetition of qualitative or semi-quantitative data obtained during the statistical analyses. The aim of this study is to summarize the methods used in histopathological evaluation of testicular tissues.Öğe Organik arayüzey tabakalı Al/CuPc /p-InP kontakların fabrikasyonu ve elektriksel parametrelerinin incelenmesi(Batman Üniversitesi, 2015-07-01) Aslan, Filiz; Güllü, Ömer; Ocak, Yusuf Selim; Rüzgar, Şerif; Tombak, Ahmet; Özaydın, Cihat; Pakma, Osman; Arsel, İsmailBu çalışmada termal buharlaştırma metodu kullanılarak bakır fitalosiyanin (CuPc) p-InP kristali üzerine kaplandı. Yine termal buharlaştırma sistemi kullanılarak oluşan ince organik film üzerine vakum ortamında alüminyum metali kaplandı ve Al/CuPc/p-InP diyot yapısı oluşturuldu. Al/CuPc/p-InP diyotunun oda sıcaklığında, karanlık ve aydınlık ortamda akım-gerilim (I-V) ölçümleri alındı. I-V grafiğinden bu yapının doğrultucu özellik gösterdiği görüldü. Aydınlık ortamda yapılan ölçümler 100 mW/cm2 ışık şiddeti altında yapıldı ve bu ölçümler doğrultusunda diyotun fotodiyot özellik gösterdiği görüldü. Ayrıca farklı yöntemlerle Al/CuPc/p-InP Schottky diyotunun karakteristik parametreleri ( idealite faktörü (n) ,engel yüksekliği (Φb) ve seri direnç (Rs) ) hesaplandı.
