Electrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetry
Küçük Resim Yok
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
ICNTC
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Attribution-NonCommercial-ShareAlike 3.0 United States
Attribution-NonCommercial-ShareAlike 3.0 United States
Özet
Vildagliptin (VLDG), one of the antidiabetic agents, is a dipeptidyl peptidase 4 inhibitor. It is
a drug developed for oral administration[1]. In the literature, there is only one study in which
electrochemical methods were used for the analysis of Vildagliptin in biological fluid and
drug forms[2]. In this study, the electrochemical properties of VLDG, which is one of the
drugs used as an antidiabetic agent, were determined by using pencil graphite electrode in
phosphate buffer solution (PBS/pH 9.0). The irreversible and diffusion controlled adsorption
oxidation peak was measured by cyclic voltammetry at approximately +1.13 V for this
compound. Using square wave stripping voltammetry, the current showed a linear correlation
in PBS buffer at pH 9.0, with a concentration range of 2.94 to 49.98 µM. At a concentration
of 2.94 µM (n=9), the limit of detection of 8.20 nM (2.48 ng mL-1
) and a relative standard
deviation of 2.95 % were calculated. This method was successfully applied for VLDG
analysis without any separation in pharmaceutical preparations and urine samples
Açıklama
Anahtar Kelimeler
Vildagliptin, Pencil Graphite Electrode, Voltammetry, Drug, Urine
Kaynak
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Altunkaynak, Y., Yavuz, Ö., Levent, A. (2020). Electrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetry. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.
