Electrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetry

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dc.authorid0000-0003-2562-9297en_US
dc.authorid0000-0002-7706-1878en_US
dc.authorid0000-0001-5792-419Xen_US
dc.contributor.authorAltunkaynak, Yalçın
dc.contributor.authorYavuz, Ömer
dc.contributor.authorLevent, Abdulkadir
dc.date.accessioned2021-03-24T09:28:18Z
dc.date.available2021-03-24T09:28:18Z
dc.date.issued2020en_US
dc.departmentBatman Üniversitesi Fen - Edebiyat Fakültesi Kimya Bölümüen_US
dc.departmentBatman Üniversitesi Teknik Bilimler Meslek Yüksekokulu Kimya ve Kimyasal İşleme Teknolojileri Bölümüen_US
dc.description.abstractVildagliptin (VLDG), one of the antidiabetic agents, is a dipeptidyl peptidase 4 inhibitor. It is a drug developed for oral administration[1]. In the literature, there is only one study in which electrochemical methods were used for the analysis of Vildagliptin in biological fluid and drug forms[2]. In this study, the electrochemical properties of VLDG, which is one of the drugs used as an antidiabetic agent, were determined by using pencil graphite electrode in phosphate buffer solution (PBS/pH 9.0). The irreversible and diffusion controlled adsorption oxidation peak was measured by cyclic voltammetry at approximately +1.13 V for this compound. Using square wave stripping voltammetry, the current showed a linear correlation in PBS buffer at pH 9.0, with a concentration range of 2.94 to 49.98 µM. At a concentration of 2.94 µM (n=9), the limit of detection of 8.20 nM (2.48 ng mL-1 ) and a relative standard deviation of 2.95 % were calculated. This method was successfully applied for VLDG analysis without any separation in pharmaceutical preparations and urine samplesen_US
dc.identifier.citationAltunkaynak, Y., Yavuz, Ö., Levent, A. (2020). Electrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetry. 6th International Conference on New Trends in Chemistry, 17-18 October 2020.en_US
dc.identifier.isbn9786056747656
dc.identifier.urihttps://hdl.handle.net/20.500.12402/2785
dc.language.isoenen_US
dc.publisherICNTCen_US
dc.relation.journal6th International Conference on New Trends in Chemistry, 17-18 October 2020en_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.subjectVildagliptinen_US
dc.subjectPencil Graphite Electrodeen_US
dc.subjectVoltammetryen_US
dc.subjectDrugen_US
dc.subjectUrineen_US
dc.titleElectrochemical oxidation of vildagliptin on pencil graphite electrode: Extremely sensitive determination in drugs and human urine with square wave voltammetryen_US
dc.typeConference Objecten_US

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Fen - Edebiyat Fakültesi, Kimya Bölümü, Bildiri Metinleri Koleksiyonu
Batman Üniversitesi, Teknik Bilimler Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü, Bildiri Metinleri Koleksiyonu